2. Academic Validation
  3. Maklamicin, an antibacterial polyketide from an endophytic Micromonospora sp

Maklamicin, an antibacterial polyketide from an endophytic Micromonospora sp

  • J Nat Prod. 2011 Apr 25;74(4):670-4. doi: 10.1021/np100727h.
Yasuhiro Igarashi 1,  Hiromu Ogura,  Kazuo Furihata,  Naoya Oku,  Chantra Indananda,  Arinthip Thamchaipenet
Affiliations

Affiliation

  • 1 Biotechnology Research Center, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan. yas@pu-toyama.ac.jp
PMID: 21388191 DOI: 10.1021/np100727h
Abstract

A new spirotetronate-class polyketide, maklamicin (1), was isolated from the culture extract of an endophytic actinomycete of the genus Micromonospora. The structure and relative configuration of 1 were elucidated by interpretation of NMR and Other spectroscopic data, and the absolute configuration was determined using the modified Mosher method. Maklamicin (1) showed strong to modest antimicrobial activity against Gram-positive bacteria.

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