2. Academic Validation
  3. Synthesis of rabdokunmin C analogues and their inhibitory effect on NF-κB activation

Synthesis of rabdokunmin C analogues and their inhibitory effect on NF-κB activation

  • Bioorg Med Chem. 2011 Apr 1;19(7):2450-7. doi: 10.1016/j.bmc.2011.02.002.
Yutaka Aoyagi 1,  Yoshiyuki Adachi,  Kei Ozawa,  Chihiro Yokomizo,  Ming-Yu Gui,  Yong-Ri Jin,  Xu-Wen Li,  Naohito Ohno,  Koichi Takeya
Affiliations

Affiliation

  • 1 School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
PMID: 21393004 DOI: 10.1016/j.bmc.2011.02.002
Abstract

A series of rabdokunmin C analogues were prepared and their inhibitory effect on NF-κB activation was assayed. One of them, 18-acetyl-12-deoxy-11,12-dehydrorabdokunmin C (16) was found to be a promising candidate for an anti-inflammatory agent.

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