2. Academic Validation
  3. Synthesis and evaluation of antibacterial activities of 5,7-dihydroxycoumarin derivatives

Synthesis and evaluation of antibacterial activities of 5,7-dihydroxycoumarin derivatives

  • Arch Pharm (Weinheim). 2011 Jun;344(6):386-93. doi: 10.1002/ardp.201000233.
Yi-Ping Chin 1,  Wei-Jan Huang,  Feng-Lin Hsu,  Yuh-Ling Lin,  Mei-Hsiang Lin
Affiliations

Affiliation

  • 1 Department of Microbiology and Immunology, Taipei Medical University, Taiwan, ROC.
PMID: 21433055 DOI: 10.1002/ardp.201000233
Abstract

This study examines the synthesis and Antibacterial activities of 5,7-dihydroxycoumarin derivatives, whose structures were confirmed using analytical and spectral data. Twenty compounds were tested for their Antibacterial activities against five microbial species such as E. coli, S. aureus, K. pneumonia, P. aeruginosa, and S. typhimurium were studied. Compounds 5 and 12 exhibited the most potent activity against Staphylococcus aureus with a MIC value of 2.5 µg/mL for each of the compounds.

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