2. Academic Validation
  3. Synthesis and anti-tumor evaluation of panaxadiol derivatives

Synthesis and anti-tumor evaluation of panaxadiol derivatives

  • Eur J Med Chem. 2011 Jun;46(6):1997-2002. doi: 10.1016/j.ejmech.2011.02.022.
Xue-Kun Liu 1,  Bai-Jun Ye,  Yan Wu,  Zhen-Hua Lin,  Yu-Qing Zhao,  Hu-Ri Piao
Affiliations

Affiliation

  • 1 Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, 1829 Juzi St., Yanji 133000, PR China.
PMID: 21439693 DOI: 10.1016/j.ejmech.2011.02.022
Abstract

A series of panaxadiol derivatives have been synthesized by the simple acylation of the 3-hydroxy group of panaxadiol. The anti-tumor activities of the synthesized compounds were evaluated against a panel of human tumor cell lines by the standard MTT assay. Compounds 2, 11, 12, 13, 14, 15 and 16 showed stronger antiproliferative activities than that of Rg3 and PD on the growth of the distinct Cancer cell lines in vitro.

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