2. Academic Validation
  3. Potent inhibitors of hepatitis C core dimerization as new leads for anti-hepatitis C agents

Potent inhibitors of hepatitis C core dimerization as new leads for anti-hepatitis C agents

  • Bioorg Med Chem Lett. 2011 Apr 15;21(8):2198-202. doi: 10.1016/j.bmcl.2011.03.014.
Feng Ni 1,  Smitha Kota,  Virginia Takahashi,  A Donny Strosberg,  John K Snyder
Affiliations

Affiliation

  • 1 Department of Chemistry and the Center for Chemical Methodology and Library Development, Boston University, 590 Commonwealth Ave, Boston, MA 02215, United States.
PMID: 21440437 DOI: 10.1016/j.bmcl.2011.03.014
Abstract

New indoline alkaloid-type compounds which inhibit HCV production by infected hepatoma cells have been identified. These compounds, dimeric-type compounds of previously known inhibitors, display double digit nanomolar IC(50) and EC(50) values, with cytotoxicity CC(50) indexes higher than 36 μM, thus providing ample therapeutic windows for further development of HCV drugs.

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