2. Academic Validation
  3. Bone morphogenetic protein (BMP)1-3 enhances bone repair

Bone morphogenetic protein (BMP)1-3 enhances bone repair

  • Biochem Biophys Res Commun. 2011 Apr 29;408(1):25-31. doi: 10.1016/j.bbrc.2011.03.109.
Lovorka Grgurevic 1,  Boris Macek,  Mladen Mercep,  Mislav Jelic,  Tomislav Smoljanovic,  Igor Erjavec,  Ivo Dumic-Cule,  Stefan Prgomet,  Dragan Durdevic,  Drazen Vnuk,  Marija Lipar,  Marko Stejskal,  Vera Kufner,  Jelena Brkljacic,  Drazen Maticic,  Slobodan Vukicevic
Affiliations

Affiliation

  • 1 Laboratory for Mineralized Tissues, Center for Translational and Clinical Research and Orthopaedic Surgery, University of Zagreb, 10000 Zagreb, Croatia.
PMID: 21453682 DOI: 10.1016/j.bbrc.2011.03.109
Abstract

Members of the astacin family of metalloproteinases such as human Bone Morphogenetic Protein 1 (BMP-1) regulate morphogenesis by processing precursors to mature functional extracellular matrix (ECM) proteins and several growth factors including TGFβ, BMP2, BMP4 and GFD8. We have recently discovered that BMP1-3 isoform of the Bmp-1 gene circulates in the human plasma and is significantly increased in patients with acute bone fracture. We hypothesized that circulating BMP1-3 might have an important role in bone repair and serve as a novel bone biomarker. When administered systemically to rats with a long bone fracture and locally to rabbits with a critical size defect of the ulna, recombinant human BMP1-3 enhanced bone healing. In contrast, neutralization of the endogenous BMP1-3 by a specific polyclonal antibody delayed the bone union. Invitro BMP1-3 increased the expression of collagen type I and osteocalcin in MC3T3-E(1) osteoblast like cells, and enhanced the formation of mineralized bone nodules from bone marrow mesenchymal stem cells. We suggest that BMP1-3 is a novel systemic regulator of bone repair.

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