1. Academic Validation
  2. Two new lignans and anti-HBV constituents from Illicium henryi

Two new lignans and anti-HBV constituents from Illicium henryi

  • Chem Biodivers. 2011 Apr;8(4):692-8. doi: 10.1002/cbdv.201000110.
Ji-Feng Liu 1 Zhi-Yong Jiang Chang-An Geng Quan Zhang Yao Shi Yun-Bao Ma Xue-Mei Zhang Ji-Jun Chen
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P. R. China.
Abstract

Two new Lignans, dihydrodehydrodiconiferyl alcohol 9-O-β-D-(3″-O-acetyl)-xylopyranoside (1) and threo-4,9,9'-trihydroxy-3,3'-dimethoxy-8-O-4'-neolignan 7-O-α-rhamnopyranoside (2) were isolated from Illicium henryi, together with ten known compounds, 3-12. Their structures were elucidated by extensive spectroscopic analyses. The anti-hepatitis B virus (anti-HBV) activity of compounds 1-12 inhibiting HBV surface antigen (HBsAg) and HBV e antigen (HBeAg) secretion on Hep G2.2.15 cell line was evaluated. (-)-Dihydrodehydrodiconiferyl alcohol (4) showed moderate inhibitory activity on both HBsAg and HBeAg secretion with IC(50) values of 0.06 and 0.53 mM, respectively.

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