2. Academic Validation
  3. Synthesis and in vitro antitumor activity of new butenolide-containing dithiocarbamates

Synthesis and in vitro antitumor activity of new butenolide-containing dithiocarbamates

  • Bioorg Med Chem Lett. 2011 May 15;21(10):3074-7. doi: 10.1016/j.bmcl.2011.03.029.
Xiao-Juan Wang 1,  Hai-Wei Xu,  Lin-Lin Guo,  Jia-Xin Zheng,  Bo Xu,  Xiao Guo,  Chen-Xin Zheng,  Hong-Min Liu
Affiliations

Affiliation

  • 1 New Drug Research & Development Center, Zhengzhou University, Zhengzhou 450001, PR China.
PMID: 21486694 DOI: 10.1016/j.bmcl.2011.03.029
Abstract

Three series of butenolide-containing dithiocarbamates were designed and synthesized. Their anti-tumor activity in vitro was evaluated. Among them compound I-14 exhibited broad spectrum anti-cancer activity against five human Cancer cell lines with IC(50) <30 μM. Structure-activity relationship analysis showed that the introduction of dithiocarbamate side chains on the C-3 position of butenolide was crucial for anti-tumor activity.

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