2. Academic Validation
  3. Synthesis of 4β-carbamoyl epipodophyllotoxins as potential antitumour agents

Synthesis of 4β-carbamoyl epipodophyllotoxins as potential antitumour agents

  • Bioorg Med Chem. 2011 May 1;19(9):2975-9. doi: 10.1016/j.bmc.2011.03.030.
Ahmed Kamal 1,  B Ashwini Kumar,  Paidakula Suresh,  Aarti Juvekar,  Surekha Zingde
Affiliations

Affiliation

  • 1 Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India. ahmedkamal@iict.res.in
PMID: 21489802 DOI: 10.1016/j.bmc.2011.03.030
Abstract

A series of new 4β-carbamoyl epipodophyllotoxin analogues have been synthesized and evaluated for their Anticancer activity against eleven Cancer cell lines including Zr-75-1, MCF7, KB, Gurav, DWD, Colo 205, A-549, Hop62, PC3, SiHa and A-2780. Most of the compounds exhibited better growth-inhibition activities against tested cell lines than that of etoposide. Further, compounds 6g and 6i are also evaluated for their DNA topoisomerase-II (topo-II) inhibition activity and they exhibited significant inhibition of topo-II catalytic activity comparable to etoposide.

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