2. Academic Validation
  3. MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome

MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome

  • Cell Metab. 2011 May 4;13(5):527-39. doi: 10.1016/j.cmet.2011.04.002.
Yolanda Cámara 1,  Jorge Asin-Cayuela,  Chan Bae Park,  Metodi D Metodiev,  Yonghong Shi,  Benedetta Ruzzenente,  Christian Kukat,  Bianca Habermann,  Rolf Wibom,  Kjell Hultenby,  Thomas Franz,  Hediye Erdjument-Bromage,  Paul Tempst,  B Martin Hallberg,  Claes M Gustafsson,  Nils-Göran Larsson
Affiliations

Affiliation

  • 1 Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
PMID: 21531335 DOI: 10.1016/j.cmet.2011.04.002
Abstract

Precise control of mitochondrial DNA gene expression is critical for regulation of Oxidative Phosphorylation capacity in mammals. The MTERF protein family plays a key role in this process, and its members have been implicated in regulation of transcription initiation and site-specific transcription termination. We now demonstrate that a member of this family, MTERF4, directly controls mitochondrial ribosomal biogenesis and translation. MTERF4 forms a stoichiometric complex with the ribosomal RNA methyltransferase NSUN4 and is necessary for recruitment of this factor to the large ribosomal subunit. Loss of MTERF4 leads to defective ribosomal assembly and a drastic reduction in translation. Our results thus show that MTERF4 is an important regulator of translation in mammalian mitochondria.

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