2. Academic Validation
  3. Synthesis of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives and their anticancer activity

Synthesis of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives and their anticancer activity

  • Eur J Med Chem. 2011 Aug;46(8):3462-8. doi: 10.1016/j.ejmech.2011.05.011.
C Kurumurthy 1,  P Sambasiva Rao,  B Veera Swamy,  G Santhosh Kumar,  P Shanthan Rao,  B Narsaiah,  L R Velatooru,  R Pamanji,  J Venkateswara Rao
Affiliations

Affiliation

  • 1 Fluoroorganic Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India.
PMID: 21632155 DOI: 10.1016/j.ejmech.2011.05.011
Abstract

A series of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives 5 and 6 was prepared starting from 2,3-active functional pyridine 1via cyclization, propargylation followed by reaction with alkyl or perfluoroalkyl azides under Sharpless conditions. All the compounds 5 and 6 were screened for Anticancer activity against three Cancer cell lines such as U(937), THP-1 and Colo205. The promising compounds 5b and 5e have been identified.

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