1. Academic Validation
  2. Flavonoid C- and O-glycosides from the Mongolian medicinal plant Dianthus versicolor Fisch

Flavonoid C- and O-glycosides from the Mongolian medicinal plant Dianthus versicolor Fisch

  • Carbohydr Res. 2011 Sep 27;346(13):1868-75. doi: 10.1016/j.carres.2011.04.031.
Astrid Obmann 1 Ingrid Werner Armin Presser Martin Zehl Zita Swoboda Sodnomtseren Purevsuren Samdan Narantuya Christa Kletter Sabine Glasl
Affiliations

Affiliation

  • 1 Department of Pharmacognosy, University of Vienna, Vienna, Austria.
Abstract

Eighteen Flavonoids were identified from an aqueous extract of the aerial parts of Dianthus versicolor, a plant used in traditional Mongolian medicine against liver diseases. The flavonoid C- and O-glycosides isoorientin-7-O-rutinoside, isoorientin-7-O-rhamnosyl-galactoside, isovitexin-7-O-rutinoside, isovitexin-7-O-rhamnosyl-galactoside, isoscoparin-7-O-rutinoside, isoscoparin-7-O-rhamnosyl-galactoside, isoscoparin-7-O-galactoside, and isoorientin-7-O-galactoside were isolated and structurally elucidated. Their structures were established on the basis of extensive spectroscopic techniques including LC-UV-DAD, LC-MS(n), LC-HRMS, 1D and 2D NMR spectroscopy, and by GC-MS analysis after hydrolysis. Flavonoids with such a high glycosylation pattern are rare within the genus Dianthus. Furthermore, isovitexin-7-O-glucoside (saponarin), isovitexin-2″-O-rhamnoside, apigenin-6-glucoside (isovitexin), luteolin-7-O-glucoside, apigenin-7-O-glucoside, as well as the aglycons luteolin, apigenin, chrysoeriol, diosmetin, and acacetin were identified by TLC and LC-DAD-MS(n) in comparison to reference substances or literature data. The NMR data of seven structures have not been reported in the literature to date.

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