2. Academic Validation
  3. Synthesis, characterization and biological evaluation of some 16β-azolyl-3β-amino-5α-androstane derivatives as potential anticancer agents

Synthesis, characterization and biological evaluation of some 16β-azolyl-3β-amino-5α-androstane derivatives as potential anticancer agents

  • Eur J Med Chem. 2011 Sep;46(9):3662-74. doi: 10.1016/j.ejmech.2011.05.030.
Hao Guo 1,  Guolan Zhang,  Tao Zhang,  Xianran He,  Zhongyuan Wu,  Yuling Xiao,  Yuanhu Pan,  Guofu Qiu,  Peng Liu,  Xianming Hu
Affiliations

Affiliation

  • 1 State Key Laboratory of Virology, Ministry of Education Laboratory of Combinatorial Biosynthesis and Drug Discovery, Wuhan University School of Pharmaceutical Science, Wuhan 430071, China.
PMID: 21641694 DOI: 10.1016/j.ejmech.2011.05.030
Abstract

A series of new 16β-azolyl-3β-amino-5α-androstane derivatives were synthesized and characterized. The new compounds were screened for their Anticancer activity against the human Cancer cell lines SW480, A549, HepG2, HeLa and SiHa in vitro using the MTT assay. The results of the in vitro study showed that a number of compounds have shown IC(50) values lower than 20 μM against the five Cancer cell lines.

Figures