2. Academic Validation
  3. Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice

Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice

  • J Med Chem. 2011 Aug 11;54(15):5444-53. doi: 10.1021/jm200476p.
Serena Pasquini 1,  Maria De Rosa,  Valentina Pedani,  Claudia Mugnaini,  Francesca Guida,  Livio Luongo,  Maria De Chiaro,  Sabatino Maione,  Stefania Dragoni,  Maria Frosini,  Alessia Ligresti,  Vincenzo Di Marzo,  Federico Corelli
Affiliations

Affiliation

  • 1 Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Siena, Italy.
PMID: 21702498 DOI: 10.1021/jm200476p
Abstract

Experimental evidence suggests that selective CB2 receptor modulators may provide access to antihyperalgesic agents devoid of psychotropic effects. Taking advantage of previous findings on structure-activity/selectivity relationships for a class of 4-quinolone-3-carboxamides, further structural modifications of the heterocyclic scaffold were explored, leading to the discovery of the 8-methoxy derivative 4a endowed with the highest affinity and selectivity ever reported for a CB2 ligand. The compound, evaluated in vivo in the formalin test, behaved as an inverse agonist by reducing at a dose of 6 mg/kg the second phase of the formalin-induced nocifensive response in mice.

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