2. Academic Validation
  3. Cytotoxic diterpenoid quinonemethides from the roots of Pygmacopremna herbacea

Cytotoxic diterpenoid quinonemethides from the roots of Pygmacopremna herbacea

  • Bioorg Med Chem Lett. 2011 Aug 1;21(15):4581-4. doi: 10.1016/j.bmcl.2011.05.109.
K Satish 1,  M V P S Vishnuvardhan,  V Lakshma Nayak,  G Srihari,  M Subrahamanyam,  T Prabhakar Rao,  S Ramakrishna,  K Ravikumar,  B Sridhar,  M Marthanda Murthy
Affiliations

Affiliation

  • 1 Organic Chemistry Division-II, Indian Institute of Chemical Technology, Hyderabad, India.
PMID: 21708464 DOI: 10.1016/j.bmcl.2011.05.109
Abstract

Two new diterpenoid quinonemethides (1 and 2) along with two known compounds (3 and 4) were isolated from the hexane and ethyl acetate extracts of root nodules of Pygmacopremna herbacea. The structures of the new compounds were established by spectroscopic data interpretation. Single crystal X-ray diffraction analysis confirmed the structure of 1. The cytotoxic activities of these compounds were evaluated against A 549, HEPG2, MCF-7, PC-3 and HELA Cancer cell lines. Compounds 4, 2 and 1 were shown very good cytotoxic activity.

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