2. Academic Validation
  3. Synthesis of aurones and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells

Synthesis of aurones and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells

  • Bioorg Med Chem Lett. 2011 Aug 1;21(15):4520-3. doi: 10.1016/j.bmcl.2011.05.117.
Seo Young Shin 1,  Min Cheol Shin,  Ji-Sun Shin,  Kyung-Tae Lee,  Yong Sup Lee
Affiliations

Affiliation

  • 1 Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.
PMID: 21723122 DOI: 10.1016/j.bmcl.2011.05.117
Abstract

Sulfuretin is one of major constituents of Rhus verniciflua that exerts anti-inflammatory activities. Some of aurones were synthesized as sulfuretin derivatives and evaluated for their abilities to inhibit NO and PGE(2) production in LPS-induced RAW 264.7 cells in order to reveal the relationship. Of the aurones synthesized in the present study, 2h and 2i, which possess C-6 hydroxyl group in A-ring and methoxy substituents in B-ring, more potently inhibited NO and PGE(2) production and were less cytotoxic than sulfuretin.

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