2. Academic Validation
  3. Bioactive sulfoximines: syntheses and properties of Vioxx analogs

Bioactive sulfoximines: syntheses and properties of Vioxx analogs

  • Bioorg Med Chem Lett. 2011 Aug 15;21(16):4888-90. doi: 10.1016/j.bmcl.2011.06.029.
Seong Jun Park 1,  Helmut Buschmann,  Carsten Bolm
Affiliations

Affiliation

  • 1 Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52056 Aachen, Germany.
PMID: 21752640 DOI: 10.1016/j.bmcl.2011.06.029
Abstract

The syntheses and biological profiles of sulfoximine-based Vioxx analogs 2 are described. Interesting data have been obtained for 2a, which shows a selective COX-2 inhibition (albeit not as strong as Vioxx itself) exhibiting reduced hERG activity compare to the parent sulfone Vioxx (1).

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