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  3. The effects of chronic trimipramine treatment on biogenic amine metabolism and on dopamine D2, 5-HT2 and tryptamine binding sites in rat brain

The effects of chronic trimipramine treatment on biogenic amine metabolism and on dopamine D2, 5-HT2 and tryptamine binding sites in rat brain

  • Gen Pharmacol. 1990;21(5):759-62. doi: 10.1016/0306-3623(90)91030-u.
A V Juorio 1,  X M Li,  A A Boulton
Affiliations

Affiliation

  • 1 Neuropsychiatric Research Unit, University of Saskatchewan, Saskatoon, Canada.
PMID: 2177438 DOI: 10.1016/0306-3623(90)91030-u
Abstract

1. Two week chronic administration of trimipramine increased the brain concentration and metabolism of dopamine and 5-hydroxytryptamine. 2. The treatment also produced a reduction in dopamine D2 and 5-hydroxytryptamine 5-HT2 receptors but no change in tryptamine binding was observed. 3. These findings suggest that trimipramine induces adaptive changes in dopamine and 5-hydroxytryptamine neurotransmission.

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