2. Academic Validation
  3. Synthesis and studies of novel 2-(4-cyano-3-trifluoromethylphenyl amino)-4-(quinoline-4-yloxy)-6-(piperazinyl/piperidinyl)-s-triazines as potential antimicrobial, antimycobacterial and anticancer agents

Synthesis and studies of novel 2-(4-cyano-3-trifluoromethylphenyl amino)-4-(quinoline-4-yloxy)-6-(piperazinyl/piperidinyl)-s-triazines as potential antimicrobial, antimycobacterial and anticancer agents

  • Eur J Med Chem. 2011 Sep;46(9):4354-65. doi: 10.1016/j.ejmech.2011.07.006.
Rahul V Patel 1,  Premlata Kumari,  Dhanji P Rajani,  Kishor H Chikhalia
Affiliations

Affiliation

  • 1 Department of Applied Chemistry, SV National Institute of Technology, Surat 395 007, Gujarat, India.
PMID: 21794959 DOI: 10.1016/j.ejmech.2011.07.006
Abstract

A series of novel s-triazine analogs were synthesized and characterized by IR, (1)H NMR, (13)C NMR, (19)F NMR spectroscopy and elemental analysis. Preliminary screening of target compounds against eight bacteria (Staphylococcus aureus, Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella typhi, Proteus vulgaris, Shigella flexneria), four fungi (Aspergillus niger, Aspergillus fumigatus, Aspergillus clavatus, Candida albicans) and Mycobacterium tuberculosis H37Rv indicated that 5d, 5h, 5n, 5p, 5q, 5r, 5s, 5t and 5u were the most active compounds among twenty one studied. Thus, they were further subjected to in vitro biological evaluation against human prostate Cancer cell line (DU-145) and the results indicate that two compounds 5n and 5s were markedly active.

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