2. Academic Validation
  3. Novel aminopeptidase N (APN/CD13) inhibitors derived from chloramphenicol amine

Novel aminopeptidase N (APN/CD13) inhibitors derived from chloramphenicol amine

  • Bioorg Med Chem. 2011 Sep 1;19(17):5190-8. doi: 10.1016/j.bmc.2011.07.008.
Meirong Jia 1,  Kanghui Yang,  Hao Fang,  Yingying Xu,  Siwei Sun,  Li Su,  Wenfang Xu
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Ji'nan, Shandong, PR China.
PMID: 21802307 DOI: 10.1016/j.bmc.2011.07.008
Abstract

Aminopeptidase N (APN) is involved in different physiological and pathological processes of tumor cells, including proliferation, invasion, Apoptosis and metastasis. Herein one series of compounds derived from commercially available (1S,2S)-2-amino-1-(4-nitrophenyl) propane-1,3-diol have been designed and synthesized. Furthermore, preliminary activity evaluation showed that some compounds elicited moderate inhibitory activity against APN with compounds 10e (IC(50)=6.1±0.5 μM) possessing the best efficacy, which could be used as the lead compound in the future for Anticancer agents research.

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