2. Academic Validation
  3. Microbial conversion of curcumin into colorless hydroderivatives by the endophytic fungus Diaporthe sp. associated with Curcuma longa

Microbial conversion of curcumin into colorless hydroderivatives by the endophytic fungus Diaporthe sp. associated with Curcuma longa

  • Chem Pharm Bull (Tokyo). 2011;59(8):1042-4. doi: 10.1248/cpb.59.1042.
Shoji Maehara 1,  Michiteru Ikeda,  Hiroyuki Haraguchi,  Chinami Kitamura,  Tetsuro Nagoe,  Kazuyoshi Ohashi,  Hirotaka Shibuya
Affiliations

Affiliation

  • 1 Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Japan.
PMID: 21804251 DOI: 10.1248/cpb.59.1042
Abstract

We investigated the microbial conversion of curcumin (1) using endophytic fungi associated with the rhizome of Curcuma longa (Zingiberaceae). We found that Diaporthe sp., an endophytic filamentous fungus, converts curcumin (1) into four colorless derivatives, namely (3R,5R)-tetrahydrocurcumin (2), a novel (3R,5S)-hexahydrocurcumin (3) named neohexahydrocurcumin, (3S,5S)-octahydrocurcumin (4) and meso-octahydrocurcumin (5).

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