2. Academic Validation
  3. Diarylheptanoids from Curcuma kwangsiensis and their inhibitory activity on nitric oxide production in lipopolysaccharide-activated macrophages

Diarylheptanoids from Curcuma kwangsiensis and their inhibitory activity on nitric oxide production in lipopolysaccharide-activated macrophages

  • Bioorg Med Chem Lett. 2011 Sep 15;21(18):5363-9. doi: 10.1016/j.bmcl.2011.07.012.
Jun Li 1,  Chun-Ru Liao,  Jun-Qi Wei,  Li-Xia Chen,  Feng Zhao,  Feng Qiu
Affiliations

Affiliation

  • 1 Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
PMID: 21807513 DOI: 10.1016/j.bmcl.2011.07.012
Abstract

Eleven diarylheptanoids (1-11) were isolated from rhizomes of Curcuma kwangsiensis, together with seven known compounds. Their structures were elucidated by 1D and 2D NMR, circular dichroism (CD), and accurate mass measurements. Inhibitory effects of the isolated compounds on nitric oxide production in lipopolysaccaride-activated macrophages were evaluated. Compounds 1, 2, and 3 showed strong inhibitory activity on NO production with IC(50) values of 3.13, 2.81 and 2.41 μM, respectively.

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