2. Academic Validation
  3. Chromomycin SA analogs from a marine-derived Streptomyces sp

Chromomycin SA analogs from a marine-derived Streptomyces sp

  • Bioorg Med Chem. 2011 Sep 1;19(17):5183-9. doi: 10.1016/j.bmc.2011.07.013.
Youcai Hu 1,  Ana Paula D M Espindola,  Nathan A Stewart,  Shuguang Wei,  Bruce A Posner,  John B MacMillan
Affiliations

Affiliation

  • 1 Department of Biochemistry, Division of Chemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9038, USA.
PMID: 21807523 DOI: 10.1016/j.bmc.2011.07.013
Abstract

Two chromomycin SA analogs, chromomycin SA(3) and chromomycin SA(2), along with deacetylchromomycin A(3) and five previously reported chromomycin analogs were isolated from a marine-derived Streptomyces sp. The structures of the new compounds were determined by spectroscopic methods including 1D and 2D NMR techniques, HRMS and chemical methods. Chromomycin SA(3) and chromomycin SA(2) are the first naturally occuring chromomycin analogs with truncated side-chains. Biological evaluation of chromomycin analogs for cytotoxicity against two non-small cell lung Cancer (NSCLC) cell-lines, A549 and HCC44, demonstrated a decrease in cytotoxicity for the truncated sides chain chromomycin analogs.

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