2. Academic Validation
  3. Quinolinyl and quinolinyl N-oxide chalcones: synthesis, antifungal and cytotoxic activities

Quinolinyl and quinolinyl N-oxide chalcones: synthesis, antifungal and cytotoxic activities

  • Eur J Med Chem. 2011 Sep;46(9):4448-56. doi: 10.1016/j.ejmech.2011.07.019.
Luciana de Carvalho Tavares 1,  Susana Johann,  Tânia Maria de Almeida Alves,  Juliana Correia Guerra,  Elaine Maria de Souza-Fagundes,  Patrícia Silva Cisalpino,  Adailton J Bortoluzzi,  Giovanni F Caramori,  Rafael de Mattos Piccoli,  Hugo T S Braibante,  Mara E F Braibante,  Moacir G Pizzolatti
Affiliations

Affiliation

  • 1 Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
PMID: 21816519 DOI: 10.1016/j.ejmech.2011.07.019
Abstract

A series of new 6-quinolinyl and quinolinyl N-oxide Chalcones were efficiently prepared. All Chalcones were tested by minimal inhibitory concentration (MIC) against three species of Candida, Cryptococcus gattii and Paracoccidioides brasiliensis. The effect of these compounds was also tested on the survival and growth of the human Cancer cell lines UACC-62 (melanoma), MCF-7 (breast), TK-10 (renal) and leukemic cells, Jurkat and HL60. The compounds tested presented strong activity against P. brasiliensis, most importantly compound 4e. C. gattii also presented interesting susceptibility for compounds 5b and 5f. The cytotoxic activity showed that compounds 3c and 4e, presented the best activity against MCF-7 and TK-10. For leukemic cells the compounds 4f, 3g, 4g and 5g have shown the best activity.

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