2. Academic Validation
  3. Quinonoid and phenazine compounds: synthesis and evaluation against H37Rv, rifampicin and isoniazid-resistance strains of Mycobacterium tuberculosis

Quinonoid and phenazine compounds: synthesis and evaluation against H37Rv, rifampicin and isoniazid-resistance strains of Mycobacterium tuberculosis

  • Eur J Med Chem. 2011 Sep;46(9):4521-9. doi: 10.1016/j.ejmech.2011.07.026.
Paula F Carneiro 1,  Maria do Carmo F R Pinto,  Tatiane S Coelho,  Bruno C Cavalcanti,  Cláudia Pessoa,  Carlos A de Simone,  Isabelle K C Nunes,  Nathalia M de Oliveira,  Renata G de Almeida,  Antonio V Pinto,  Kelly C G de Moura,  Pedro A da Silva,  Eufrânio N da Silva Júnior
Affiliations

Affiliation

  • 1 Núcleo de Pesquisas de Produtos Naturais, UFRJ, 21941-971 Rio de Janeiro, Brazil.
PMID: 21820768 DOI: 10.1016/j.ejmech.2011.07.026
Abstract

Several quinonoid and phenazine compounds were synthesized in moderate to high yields and showed activity against H(37)Rv, rifampicin and isoniazid-resistance strains of Mycobacterium tuberculosis. The cytotoxity of the compounds were evaluated against human peripheral blood mononuclear cells (PBMC) and these substances emerge as promising antitubercular prototypes.

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