2. Academic Validation
  3. Novel thiophenyl C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents

Novel thiophenyl C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents

  • Bioorg Med Chem. 2011 Oct 1;19(19):5813-32. doi: 10.1016/j.bmc.2011.08.014.
Suk Ho Lee 1,  Kwang-Seop Song,  Jong Yup Kim,  Misuk Kang,  Jun Sung Lee,  Seung-Hwan Cho,  Hyun-Ju Park,  Jeongmin Kim,  Jinhwa Lee
Affiliations

Affiliation

  • 1 Research Center, Green Cross Corporation, 303 Bojeong-Dong, Giheung-Gu, Yongin, Gyeonggi-Do 446-770, Republic of Korea.
PMID: 21906953 DOI: 10.1016/j.bmc.2011.08.014
Abstract

Novel thiophene C-aryl glucoside SGLT2 inhibitors were designed and synthesized. Two different types of thiophene derivatives were readily prepared. Among the compounds tested, ethylphenyl at the distal ring 71p showed the best in vitro inhibitory activity in this series to date (IC(50)=4.47 nM) against SGLT2.

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