2. Academic Validation
  3. Bioactive metabolites from biotransformation of paeonol by the white-rot basidiomycete Coriolus versicolor

Bioactive metabolites from biotransformation of paeonol by the white-rot basidiomycete Coriolus versicolor

  • Nat Prod Commun. 2011 Aug;6(8):1129-30.
Xiao-Jun Li 1,  Xin-Wei Shi,  Qi Shuai,  Jin-Ming Gao,  An-Ling Zhang
Affiliations

Affiliation

  • 1 Research Centre for Natural Medicinal Chemistry, College of Science, Northwest A & F University, Yangling, Shaanxi 712100, China.
PMID: 21922916
Abstract

Biotransformation of paeonol (1) with the white-rot basidiomycete Coriolus versicolor afforded two metabolites, 2,4-dihydroxyacetophenone (2) and 2,5-dihydroxy-4-methoxyacetophenone (3), which were identified by spectroscopic methods. Compound 3 showed higher antioxidative, Antibacterial, Antifungal activities than 1 or 2. The results demonstrate for the first time that C. versicolor has the capacities to catalyze hydroxylation and demethylation reactions on the aromatic compound.

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