1. Academic Validation
  2. Antinociceptive properties of bergenin

Antinociceptive properties of bergenin

  • J Nat Prod. 2011 Oct 28;74(10):2062-8. doi: 10.1021/np200232s.
Cristiane Metzker de Oliveira 1 Fabiana Regina Nonato Flávia Oliveira de Lima Ricardo David Couto Juceni P David Jorge M David Milena Botelho Pereira Soares Cristiane Flora Villarreal
Affiliations

Affiliation

  • 1 Universidade Federal da Bahia, and Centro de Biotecnologia e Terapia Celular, Hospital São Rafael, Salvador, BA, Brazil.
Abstract

Bergenin (1) is a C-glucoside of 4-O-methylgallic acid with known antiarthritic activity attributed to modulation of cytokine production. The present study was undertaken to evaluate whether 1 has antinociceptive properties in models of inflammatory pain and to investigate its possible mechanisms of action. Pretreatment with 1 (12.5-100 mg/kg, ip) produced a dose-related inhibition of acetic acid-induced writhing in mice. Furthermore, treatment with 1 (50 and 100 mg/kg) inhibited both the early and late phases in a formalin test. In addition, 1 (50 and 100 mg/kg, ip) inhibited mechanical hyperalgesia, edema, and paw production of hyperalgesic cytokines (TNF-α and IL-1β) induced by complete Freund's Adjuvant. However, the local production of IL-10, an anti-inflammatory cytokine, was not altered by 1 (100 mg/kg, ip). Treatment with 1 produced a similar profile of antinociception in wild-type and IL-10-deficient mice. Mice treated with 1 did not show any motor performance alterations or apparent systemic toxicity. The results presented herein demonstrate that bergenin has consistent antinociceptive and anti-inflammatory properties, acting by the inhibition of IL-1β and TNF-α production, and suggest its potential for the control of inflammatory pain.

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