2. Academic Validation
  3. Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents

Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents

  • Bioorg Med Chem Lett. 2011 Nov 15;21(22):6788-92. doi: 10.1016/j.bmcl.2011.09.034.
Hong-wang Zhang 1,  Longhu Zhou,  Steven J Coats,  Tamara R McBrayer,  Phillip M Tharnish,  Lavanya Bondada,  Mervi Detorio,  Sarah A Amichai,  Melissa D Johns,  Tony Whitaker,  Raymond F Schinazi
Affiliations

Affiliation

  • 1 Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
PMID: 21983447 DOI: 10.1016/j.bmcl.2011.09.034
Abstract

Based on the anti-hepatitis C activity of 2'-C-methyl-adenosine and 2'-C-methyl-guanosine, a series of new modified purine 2'-C-methyl nucleosides was prepared as potential anti-hepatitis C virus agents. Herein, we report the synthesis of both 6-modified and 2-modified purine 2'-C-methyl-nucleosides along with their anti-HCV replication activity and cytotoxicity in different cells.

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