2. Academic Validation
  3. Cytotoxic and antimalarial azaphilones from Chaetomium longirostre

Cytotoxic and antimalarial azaphilones from Chaetomium longirostre

  • J Nat Prod. 2011 Nov 28;74(11):2395-9. doi: 10.1021/np2004903.
Natcha Panthama 1,  Somdej Kanokmedhakul,  Kwanjai Kanokmedhakul,  Kasem Soytong
Affiliations

Affiliation

  • 1 Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
PMID: 22004007 DOI: 10.1021/np2004903
Abstract

Four new azaphilones named longirostrerones A-D (1-4) and three known sterols, ergosteryl palmitate, ergosterol, and ergosterol peroxide, have been isolated from ethyl acetate extract of the fungus Chaetomium longirostre. These structures were determined by 1D and 2D NMR, IR, UV, MS, and CD spectroscopy. Compounds 1-4 exhibited strong cytotoxicity against KB Cancer cell lines (IC(50) 0.23-6.38 μM), while only 1 showed potent cytotoxicity against MCF7 and NCI-H187 cell lines (IC50 0.24 and 3.08 μM, respectively). In addition, 1-3 showed antimalarial activity against Plasmodium falciparum (IC50 0.62-3.73 μM).

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