2. Academic Validation
  3. Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors

Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors

  • Bioorg Med Chem. 2011 Dec 1;19(23):7120-8. doi: 10.1016/j.bmc.2011.09.062.
Bini Mathew 1,  Shefali Srivastava,  Larry J Ross,  William J Suling,  E Lucile White,  Lisa K Woolhiser,  Anne J Lenaerts,  Robert C Reynolds
Affiliations

Affiliation

  • 1 Drug Discovery Division, Southern Research Institute, 2000 Ninth Avenue South, Birmingham, AL 35205, USA.
PMID: 22024272 DOI: 10.1016/j.bmc.2011.09.062
Abstract

A series of pyridopyrazine and pyrimidothiazine derivatives have been synthesized and their activity against FtsZ from Mycobacterium tuberculosis (Mtb) and in vitro Antibacterial activity against Mtb H(37)Ra and Mtb H(37)Rv are reported. Certain analogs described herein showed moderate to good inhibitory activity.

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