2. Academic Validation
  3. Janthinocins A, B and C, novel peptide lactone antibiotics produced by Janthinobacterium lividum. II. Structure elucidation

Janthinocins A, B and C, novel peptide lactone antibiotics produced by Janthinobacterium lividum. II. Structure elucidation

  • J Antibiot (Tokyo). 1990 Aug;43(8):920-30. doi: 10.7164/antibiotics.43.920.
J H Johnson 1,  A A Tymiak,  M S Bolgar
Affiliations

Affiliation

  • 1 Squibb Institute for Medical Research, Princeton, NJ 08543-4000.
PMID: 2211360 DOI: 10.7164/antibiotics.43.920
Abstract

The structures of janthinocins A, B and C, three novel macrocyclic peptide lactone Antibiotics isolated from fermentations of Janthinobacterium lividum, were determined. The janthinocins are of particular interest because they contain three amino acid residues that have not previously been reported in natural products: Each contains erythro-beta-hydroxy-D-leucine while janthinocins A and B also contain beta-hydroxytryptophan and beta-ketotryptophan, respectively.

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