2. Academic Validation
  3. Synthesis of rocaglamide hydroxamates and related compounds as eukaryotic translation inhibitors: synthetic and biological studies

Synthesis of rocaglamide hydroxamates and related compounds as eukaryotic translation inhibitors: synthetic and biological studies

  • J Med Chem. 2012 Jan 12;55(1):558-62. doi: 10.1021/jm201263k.
Christina M Rodrigo 1,  Regina Cencic,  Stéphane P Roche,  Jerry Pelletier,  John A Porco
Affiliations

Affiliation

  • 1 Department of Chemistry, Center for Chemical Methodology and Library Development (CMLD-BU), Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
PMID: 22128783 DOI: 10.1021/jm201263k
Abstract

The rocaglates/rocaglamides are a class of Natural Products known to display potent Anticancer activity. One such derivative, silvestrol, has shown activity comparable to taxol in certain settings. Here, we report the synthesis of various rocaglamide analogues and identification of a hydroxamate derivative (-)-9 having activity similar to silvestrol in vitro and ex vivo for inhibition of protein synthesis. We also show that (-)-9 synergizes with doxorubicin in vivo to reduce Eμ-Myc driven lymphomas.

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