2. Academic Validation
  3. BAG2 is a target of the c-Myc gene and is involved in cellular senescence via the p21(CIP1) pathway

BAG2 is a target of the c-Myc gene and is involved in cellular senescence via the p21(CIP1) pathway

  • Cancer Lett. 2012 May 1;318(1):34-41. doi: 10.1016/j.canlet.2011.11.033.
Ju Zhang 1,  Xiaomin Lou,  Shangbin Yang,  Shun He,  Lei Yang,  Mei Liu,  Hongxia Zhu,  Qiang Shan,  Siyuan Su,  Qimin Zhan,  Ningzhi Xu,  Siqi Liu
Affiliations

Affiliation

  • 1 Laboratory of Synthetic Biology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
PMID: 22146591 DOI: 10.1016/j.canlet.2011.11.033
Abstract

Suppression of c-Myc is likely to induce cellular senescence in many tumors with unclear mechanisms. A proteomics survey indicated that high levels of BCL2-associated athanogene 2 (BAG2) were found in response to c-Myc repression in TRE293 cells. This observation led to the investigation into the role of BAG2 in c-Myc-induced senescence. The association of the c-Myc/SP1 complex with the BAG2 promoter verified the role of c-Myc/SP1 in regulating BAG2 transcription. Furthermore, high levels of BAG2 were found to induce p21(CIP1)-dependent senescence and subsequent carcinogenetic arrest, suggesting its possible role as an indirect activator of the p21(CIP1) pathway.

Figures
Products