2. Academic Validation
  3. Cyclopeptide Alkaloids from Ziziphus apetala

Cyclopeptide Alkaloids from Ziziphus apetala

  • J Nat Prod. 2011 Dec 27;74(12):2571-5. doi: 10.1021/np200755t.
Jing Han 1,  Chang-Jiu Ji,  Wen-Jun He,  Yu Shen,  Ying Leng,  Wen-Yan Xu,  Jun-Ting Fan,  Guang-Zhi Zeng,  Ling-Dong Kong,  Ning-Hua Tan
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China.
PMID: 22148241 DOI: 10.1021/np200755t
Abstract

Six novel Ia₃-type cyclopeptide Alkaloids (1-6) were isolated from stems of Ziziphus apetala. Compound 5 and the known compounds mauritine A (7) and mauritine F (8) were isolated from the roots. Their structures were determined by spectroscopic analyses and chemical methods. The total Alkaloids from the roots and the isolated cyclopeptide Alkaloids were tested for antidepressant behavior on mice, cytotoxicity, and 11β-hydroxysteroid dehydrogenase (11β-HSD) inhibition in vitro. Only mauritine A (7) showed inhibitory activity on 11β-HSD1, with IC₅₀ values of 52.0 (human) and 31.2 μg/mL (mouse).

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