2. Academic Validation
  3. Synthesis of novel 2, 5-dihydrofuran derivatives and evaluation of their anticancer activity

Synthesis of novel 2, 5-dihydrofuran derivatives and evaluation of their anticancer activity

  • Eur J Med Chem. 2012 Feb:48:69-80. doi: 10.1016/j.ejmech.2011.11.036.
Yikai Zhang 1,  Hanyu Zhong,  Tiantian Wang,  Dongping Geng,  Mingfeng Zhang,  Ke Li
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, People's Republic of China.
PMID: 22182926 DOI: 10.1016/j.ejmech.2011.11.036
Abstract

According to metal-catalyzed [3 + 2] cycloaddition reaction, we synthesized a series of novel 2, 5-dihydrofuran derivatives and evaluated their in vitro anti-cancer activities via MTT method. The bioassay showed that the majority of the resultant compounds exerted anti-tumor effect against four human Cancer cell lines to various extents, which supported the rationale of the design. Compounds 9e and 10g showed the highest activity with broad anti-cancer spectrum, which were good candidates for further evaluation.

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