2. Academic Validation
  3. Symmetric dimers of ent-kaurane diterpenoids with cytotoxic activity from Croton tonkinensis

Symmetric dimers of ent-kaurane diterpenoids with cytotoxic activity from Croton tonkinensis

  • Bioorg Med Chem Lett. 2012 Jan 15;22(2):1122-4. doi: 10.1016/j.bmcl.2011.11.116.
Phuong Thien Thuong 1,  Thi Hong Minh Pham,  Thi Van Thu Le,  Trong Tuan Dao,  Thai Trung Dang,  Quyet Tien Nguyen,  Won Keun Oh
Affiliations

Affiliation

  • 1 Vietnam National Institute of Medicinal Materials, 3B Quangtrung, Hoankiem, Hanoi, Viet Nam.
PMID: 22197145 DOI: 10.1016/j.bmcl.2011.11.116
Abstract

Breast Cancer is the most common malignant tumor in women these days accounting for approximately 24% of all Cancer. During our screening program searching for cytotoxic Materials from Natural Products, two new symmetric dimers of ent-kaurane diterpenoid, crotonkinensins C (1) and D (2), with connectivity at C-17 were isolated from the leaves of the Vietnamese endemic medicinal plant Croton tonkinensis. Their structures were determined on the basis of physicochemical and spectroscopic data. Compound 2 showed a potent cytotoxic activity against MCF-7, tamoxifen-resistant MCF-7 (MCF-7/TAMR), adriamycin-resistant MCF-7 (MCF-7/ADR), and MDA-MB-231 breast Cancer cell lines.

Figures