2. Academic Validation
  3. Synthesis and antimicrobial activity of 2,3-bis(bromomethyl)quinoxaline derivatives

Synthesis and antimicrobial activity of 2,3-bis(bromomethyl)quinoxaline derivatives

  • Bioorg Chem. 2012 Apr-Jun;41-42:1-5. doi: 10.1016/j.bioorg.2011.12.002.
Hisato Ishikawa 1,  Takayuki Sugiyama,  Keisuke Kurita,  Akihiro Yokoyama
Affiliations

Affiliation

  • 1 Department of Materials and Life Science, Faculty of Science and Technology, Seikei University, 3-3-1, Kichijoji-kitamachi, Musashino, Tokyo 180-8633, Japan.
PMID: 22245018 DOI: 10.1016/j.bioorg.2011.12.002
Abstract

We synthesized 12 derivatives of 2,3-bis(bromomethyl)quinoxaline with substituents at the 6- and/or 7-positions, and evaluated their activities against bacteria and fungi. Of the 12 compounds, nine (1a-h, 1j, and 1k) showed Antibacterial activity. The derivative 1g, which bears a trifluoromethyl group at the 6-position, showed the highest activity against Gram-positive bacteria, while 1c, which has a fluoro-group at the 6-position, showed the widest Antifungal activity spectrum. However, only the derivative with an ethyl ester substitution, 1k showed activity against Gram-negative bacteria.

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