2. Academic Validation
  3. Synthesis and antiplasmodial evaluation of novel chromeno[2,3-b]chromene derivatives

Synthesis and antiplasmodial evaluation of novel chromeno[2,3-b]chromene derivatives

  • Bioorg Med Chem. 2012 Feb 15;20(4):1527-34. doi: 10.1016/j.bmc.2011.12.037.
Ruth Devakaram 1,  David StC Black,  Vanida Choomuenwai,  Rohan A Davis,  Naresh Kumar
Affiliations

Affiliation

  • 1 School of Chemistry, The University of New South Wales, UNSW, Sydney, NSW 2052, Australia.
PMID: 22269277 DOI: 10.1016/j.bmc.2011.12.037
Abstract

5-Methoxyflavenes and 6-methoxyflavenes were found to undergo stereoselective acid-catalyzed rearrangement to generate a range of novel chromeno[2,3-b]chromene derivatives. When subjected to an in vitro antiplasmodial growth inhibition assay using Plasmodium falciparum (3D7 line) the chromene analogues were shown to display IC(50) values ranging from 6.8 to 39.8 μM.

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