2. Academic Validation
  3. Cytotoxic phloroglucinols from the leaves of Myrtus communis

Cytotoxic phloroglucinols from the leaves of Myrtus communis

  • J Nat Prod. 2012 Feb 24;75(2):225-9. doi: 10.1021/np2009219.
Filippo Cottiglia 1,  Laura Casu,  Marco Leonti,  Pierluigi Caboni,  Costantino Floris,  Bernardetta Busonera,  Pamela Farci,  Aicha Ouhtit,  Giuseppina Sanna
Affiliations

Affiliation

  • 1 Dipartimento Farmaco Chimico Tecnologico, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy. cottiglf@unica.it
PMID: 22276775 DOI: 10.1021/np2009219
Abstract

Bioactivity-guided fractionation of a dichloromethane extract of the leaves of Myrtus communis led to the isolation of phloroglucinol derivatives. The structures of the new myrtucommulones J, K, and L (1-3) and the previously known myrtucommulone A (4) were elucidated on the basis of extensive 1D and 2D NMR experiments as well as high-resolutionmass spectrometry. Myrtucommulone J was obtained as a tautomeric pair (1/1a). The compounds were tested in vitro for their cytotoxic and Antibacterial activities.

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