2. Academic Validation
  3. Cytotoxic angucycline class glycosides from the deep sea actinomycete Streptomyces lusitanus SCSIO LR32

Cytotoxic angucycline class glycosides from the deep sea actinomycete Streptomyces lusitanus SCSIO LR32

  • J Nat Prod. 2012 Feb 24;75(2):202-8. doi: 10.1021/np2008335.
Hongbo Huang 1,  Tingting Yang,  Xiangmei Ren,  Jing Liu,  Yongxiang Song,  Aijun Sun,  Junying Ma,  Bo Wang,  Yun Zhang,  Caiguo Huang,  Changsheng Zhang,  Jianhua Ju
Affiliations

Affiliation

  • 1 Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, People's Republic of China.
PMID: 22304344 DOI: 10.1021/np2008335
Abstract

Five new C-glycoside angucyclines, named grincamycins B-F (1-5), and a known angucycline Antibiotic, grincamycin (6), were isolated from Streptomyces lusitanus SCSIO LR32, an actinomycete of deep sea origin. The structures of these compounds were elucidated on the basis of extensive spectroscopic analyses, including MS and 1D and 2D NMR experiments. All compounds except grincamycin F (5) exhibited in vitro cytotoxicities against the human Cancer cell lines HepG2, SW-1990, HeLa, NCI-H460, and MCF-7 and the mouse melanoma cell line B16, with IC₅₀ values ranging from 1.1 to 31 μM.

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