2. Academic Validation
  3. A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells

A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells

  • Bioorg Med Chem Lett. 2012 Mar 1;22(5):2114-8. doi: 10.1016/j.bmcl.2011.12.095.
Guanghui Wang 1,  Xiaoyu Guo,  Haifeng Chen,  Ting Lin,  Yang Xu,  Quancheng Chen,  Jie Liu,  Jinzhang Zeng,  Xiao-Kun Zhang,  Xinsheng Yao
Affiliations

Affiliation

  • 1 School of Pharmaceutical Sciences, Xiamen University, 422 South Siming Road, Xiamen, Fujian 361005, PR China.
PMID: 22326393 DOI: 10.1016/j.bmcl.2011.12.095
Abstract

Among the seven natural resveratrol analogs separated and identified from Pholidota yunnanensis R(OLFE), we found phoyunbene B (PYB, trans-3,4'-dihydroxy-2',3',5-trimethoxystilbene) was more effective in inhibiting the growth of HepG2 hepatocellular carcinoma cells than resveratrol. The inhibitory effect of PYB in HepG2 cells was due to its induction of G2/M cell cycle arrest and Apoptosis. Induction of G2/M phase cell cycle arrest by PYB was associated with its up-regulation of Cyclin B1, while its induction of Apoptosis was accompanied with its down-regulation of Bcl-2 and up-regulation of Bax. Our in vitro invasion/migration assays also showed that PYB could inhibit the invasion of hepatocellular carcinoma cells.

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