2. Academic Validation
  3. TNPO3 is required for HIV-1 replication after nuclear import but prior to integration and binds the HIV-1 core

TNPO3 is required for HIV-1 replication after nuclear import but prior to integration and binds the HIV-1 core

  • J Virol. 2012 May;86(10):5931-6. doi: 10.1128/JVI.00451-12.
Jose Carlos Valle-Casuso 1,  Francesca Di Nunzio,  Yang Yang,  Natalia Reszka,  Maritza Lienlaf,  Nathalie Arhel,  Patricio Perez,  Abraham L Brass,  Felipe Diaz-Griffero
Affiliations

Affiliation

  • 1 Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
PMID: 22398280 DOI: 10.1128/JVI.00451-12
Abstract

TNPO3 is a nuclear importer required for HIV-1 Infection. Here, we show that depletion of TNPO3 leads to an HIV-1 block after nuclear import but prior to integration. To investigate the mechanistic requirement of TNPO3 in HIV-1 Infection, we tested the binding of TNPO3 to the HIV-1 core and found that TNPO3 binds to the HIV-1 core. Overall, this work suggests that TNPO3 interacts with the incoming HIV-1 core in the cytoplasm to assist a process that is important for HIV-1 Infection after nuclear import.

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