2. Academic Validation
  3. Phosphonium lipocations as antiparasitic agents

Phosphonium lipocations as antiparasitic agents

  • Bioorg Med Chem Lett. 2012 Apr 15;22(8):2976-9. doi: 10.1016/j.bmcl.2012.02.045.
Timothy E Long 1,  Xiao Lu,  Melina Galizzi,  Roberto Docampo,  Jiri Gut,  Philip J Rosenthal
Affiliations

Affiliation

  • 1 Department of Pharmaceutical and Biomedical Sciences and Center for Drug Discovery, University of Georgia, Athens, GA 30602, USA. tlong@rx.uga.edu
PMID: 22414614 DOI: 10.1016/j.bmcl.2012.02.045
Abstract

Phosphonium lipocations were synthesized and evaluated for inhibition of the development of Plasmodium falciparum and Trypanosoma cruzi, etiological agents of malaria and Chagas disease, respectively. Optimal phthalimides and 1,4-naphthoquinone-based lipocations were active in vitro at mid-high nM concentrations against P. falciparum and low μM concentrations against T. cruzi.

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