2. Academic Validation
  3. Octanoic acid suppresses harmaline-induced tremor in mouse model of essential tremor

Octanoic acid suppresses harmaline-induced tremor in mouse model of essential tremor

  • Neurotherapeutics. 2012 Jul;9(3):635-8. doi: 10.1007/s13311-012-0121-1.
Fatta B Nahab 1,  Adrian Handforth,  Tyler Brown,  Christopher Shin,  Arnulfo Quesada,  Chuanhui Dong,  Dietrich Haubenberger,  Mark Hallett
Affiliations

Affiliation

  • 1 Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA. fnahab@med.miami.edu
PMID: 22454323 DOI: 10.1007/s13311-012-0121-1
Abstract

Recent work exploring the use of high-molecular weight alcohols to treat essential tremor (ET) has identified octanoic acid as a potential novel tremor-suppressing agent. We used an established harmaline-based mouse model of ET to compare tremor suppression by 1-octanol and octanoic acid. The dose-related effect on digitized motion power within the tremor bandwidth as a fraction of overall motion power was analyzed. Both 1-octanol and octanoic acid provided significant reductions in harmaline tremor. An 8-carbon alkyl alcohol and carboxylic acid each suppress tremor in a pre-clinical mouse model of ET. Further studies are warranted to determine the safety and efficacy of such agents in humans with ET.

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