Buclizine

A comprehensive profile on buclizine hydrochloride, the piperazine derivative which is a sedating antihistamine with antimuscarinic and moderate sedative action and used mainly for its antiemetic effect in the prevention of motion sickness and migraine, is prepared. This profile contains the following sections: description, uses and applications, methods of preparation, physical characteristics, methods of analysis and stability. The physical characteristics section includes solubility, melting range, X-ray powder diffraction pattern, ultraviolet/visible spectroscopy, infrared spectroscopy, proton and carbon-13 nuclear magnetic resonance spectrometry, and mass spectrometry. Methods of analysis section includes compendial BP methods, spectrophotometry, potentiometry, and chromatography (TLC, GC, HPLC).