2. Academic Validation
  3. Cytotoxic cytochalasins from the endozoic fungus Phoma sp. of the giant jellyfish Nemopilema nomurai

Cytotoxic cytochalasins from the endozoic fungus Phoma sp. of the giant jellyfish Nemopilema nomurai

  • Bioorg Med Chem Lett. 2012 May 1;22(9):3126-9. doi: 10.1016/j.bmcl.2012.03.058.
Eun La Kim 1,  Jian Lin Li,  Hung The Dang,  Jongki Hong,  Chong-Ok Lee,  Dong-Kyoo Kim,  Won Duk Yoon,  Euikyung Kim,  Yonghong Liu,  Jee H Jung
Affiliations

Affiliation

  • 1 College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
PMID: 22483395 DOI: 10.1016/j.bmcl.2012.03.058
Abstract

Four new cytochalasin derivatives (1-4), together with cytochalasin B (5), were isolated from the fungus Phoma sp. obtained from the giant jellyfish Nemopilema nomurai. The planar structure and relative stereochemistry were established by analysis of 1D and 2D NMR data. The absolute configuration was defined by the modified Mosher's method. The compounds showed significant cytotoxicity against a small panel of human solid tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF 498, and HCT15) with IC(50) values in the range of 0.5-30 μM. The cytochalasin B (5) showed obvious cytotoxicity with IC(50) of 7.9 μM against HeLa human cervical carcinoma cells.

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