2. Academic Validation
  3. Solvent effect on copper-catalyzed azide-alkyne cycloaddition (CuAAC): synthesis of novel triazolyl substituted quinolines as potential anticancer agents

Solvent effect on copper-catalyzed azide-alkyne cycloaddition (CuAAC): synthesis of novel triazolyl substituted quinolines as potential anticancer agents

  • Bioorg Med Chem Lett. 2012 May 15;22(10):3455-9. doi: 10.1016/j.bmcl.2012.03.091.
Amarender Reddy Ellanki 1,  Aminul Islam,  Veera Swamy Rama,  Ranga Prasad Pulipati,  D Rambabu,  G Rama Krishna,  C Malla Reddy,  K Mukkanti,  G R Vanaja,  Arunasree M Kalle,  K Shiva Kumar,  Manojit Pal
Affiliations

Affiliation

  • 1 Chemistry-Technology Development Center, Dr. Reddy's Laboratories Limited, Miyapur, Hyderabad, Andhra Pradesh, India.
PMID: 22516283 DOI: 10.1016/j.bmcl.2012.03.091
Abstract

A regioselective route to novel mono triazolyl substituted quinolines has been developed via copper-catalyzed azide-alkyne cycloaddition (CuAAC) of 2,4-diazidoquinoline with terminal alkynes in DMF. The reaction provided bis triazolyl substituted quinolines when performed in water in the presence of Et(3)N. A number of the compounds synthesized showed promising anti-proliferative properties when tested in vitro especially against breast Cancer cells.

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