2. Academic Validation
  3. Quinazoline-tyrphostin as a new class of antitumor agents, molecular properties prediction, synthesis and biological testing

Quinazoline-tyrphostin as a new class of antitumor agents, molecular properties prediction, synthesis and biological testing

  • Eur J Med Chem. 2012 Jul:53:133-40. doi: 10.1016/j.ejmech.2012.03.044.
Ahmed M Alafeefy 1,  Saleh I Alqasoumi,  Abdelkader E Ashour,  Vijay Masand,  Nabila A Al-Jaber,  Taibi Ben Hadda,  Menshawy A Mohamed
Affiliations

Affiliation

  • 1 Department of Pharmaceutical Chemistry, College of Pharmacy, Salman Bin Abdulaziz University, PO Box 173, Alkharj 11942, Saudi Arabia. ahmed.alafeefy@yahoo.com
PMID: 22520152 DOI: 10.1016/j.ejmech.2012.03.044
Abstract

A new series of substituted quinazolin-4-(3H)-one-tyrphostin derivatives was prepared and screened for their cytotoxic activity against three tumor cell lines, namely human breast Cancer cell line (MCF-7), human cervical Cancer cell line (HeLa) and human hepatocellular liver carcinoma cell line (HepG2) using the colorimetric MTT assay. Among the current series, 10 compounds exhibited remarkable in vitro antiproliferative activity against the three tested cell lines with the IC(50) values ranging from 0.009 to 0.015 mM. All the compounds showed suitable drug like characteristics according to Lipinski's rule.

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