2. Academic Validation
  3. Wake promoting agents: search for next generation modafinil, lessons learned: part III

Wake promoting agents: search for next generation modafinil, lessons learned: part III

  • Bioorg Med Chem Lett. 2012 Jun 1;22(11):3751-3. doi: 10.1016/j.bmcl.2012.04.031.
Derek Dunn 1,  Greg Hostetler,  Mohamed Iqbal,  Val R Marcy,  Yin Guo Lin,  Bruce Jones,  Lisa D Aimone,  John Gruner,  Mark A Ator,  Edward R Bacon,  Sankar Chatterjee
Affiliations

Affiliation

  • 1 Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA.
PMID: 22546675 DOI: 10.1016/j.bmcl.2012.04.031
Abstract

In searching for a next generation molecule to the novel wake promoting agent modafinil (compound 1), a series of fluorene-derived wakefulness enhancing agents were developed and evaluated in rat. Extensive pharmacokinetic studies of a potent member of the series (compound 15) revealed that the wake promotion activity of the analog was likely due to an active metabolite (compound 3).

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